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Related Concept Videos

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

Updated: Feb 24, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Visual Evoked Potentials in Primary Open Angle Glaucoma.

Mukesh Kumar Jha1, Dilip Thakur2, Nirmala Limbu2

  • 1Department of Physiology, Kathmandu University School of Medical Sciences, Dhulikhel, Kavre, Nepal.

Journal of Neurodegenerative Diseases
|August 16, 2017
PubMed
Summary
This summary is machine-generated.

Primary open-angle glaucoma (POAG) is linked to visual pathway damage, as shown by prolonged visual evoked potentials (VEPs). These VEP changes indicate glaucomatous damage to the optic pathway in POAG patients.

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Medical Imaging

Background:

  • Visual evoked potentials (VEPs) evaluate the visual pathway's integrity from the optic nerve to the occipital cortex.
  • Optic disc cupping and visual field loss are associated with prolonged VEP latency in primary open-angle glaucoma (POAG).

Purpose of the Study:

  • To investigate the relationship between primary open-angle glaucoma (POAG) and visual evoked potential (VEP) abnormalities.
  • To assess the impact of POAG on the visual pathways using VEP testing.

Main Methods:

  • Pattern reversal and flash VEP tests were performed.
  • The study included 20 eyes with POAG and 40 normal control eyes.

Main Results:

  • POAG eyes showed significantly higher refractive error, cup-disc ratio, intraocular pressure, and visual field pattern standard deviation compared to controls.
  • POAG eyes exhibited reduced visual acuity, foveal visual sensitivity, and visual field mean deviation.
  • Specific VEP parameters, including pattern reversal latency N145 and flash amplitudes N75 and N145, were increased in POAG cases, while pattern reversal amplitudes N75, P100, and N145 were decreased.

Conclusions:

  • Primary open-angle glaucoma (POAG) leads to glaucomatous damage in the optic pathway.
  • VEP testing can reveal significant alterations in visual pathway function in POAG.