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Staphylococcus aureus CidC Is a Pyruvate:Menaquinone Oxidoreductase

Xinyan Zhang1, Kenneth W Bayles1, Sorin Luca1

  • 1Department of Pharmaceutical Sciences and ‡Department of Pathology & Microbiology, University of Nebraska Medical Center , Omaha, Nebraska 68198-5900, United States.

Biochemistry
|August 16, 2017
PubMed
Summary

The Staphylococcus aureus CidC enzyme, crucial for bacterial programmed cell death (PCD), catalyzes pyruvate oxidation. Its activity increases at acidic pH and is linked to the cell membrane, aiding PCD induction.

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