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P Walder1, L Paša, L Pavliska

  • 1Ortopedické oddělení Fakultní nemocnice Ostrava.

Acta Chirurgiae Orthopaedicae Et Traumatologiae Cechoslovaca
|August 16, 2017
PubMed
Summary

Platelet- and leukocyte-rich plasma (L-PRP) offers a superior functional recovery for lateral humeral epicondylitis compared to corticosteroid injections. Both treatments show similar pain relief, but L-PRP provides more sustained benefits.

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Area of Science:

  • Orthopedics
  • Regenerative Medicine
  • Sports Medicine

Background:

  • Lateral humeral epicondylitis (ERH) is a common condition causing elbow pain.
  • Current treatments include corticosteroid injections, which offer temporary relief.
  • Platelet-rich plasma (PRP) therapies are emerging as potential alternatives.

Purpose of the Study:

  • To compare the safety and efficacy of leukocyte-rich platelet- and leukocyte-rich plasma (L-PRP) versus corticosteroid therapy for ERH.
  • To evaluate functional outcomes and pain reduction over a 12-month follow-up period.

Main Methods:

  • A prospective, double-blind, randomized clinical trial involving 25 cases of ERH.
  • Two treatment arms: L-PRP (native and thawed applications) and corticosteroid (Betamethasonum).
  • Efficacy assessed using DASH score and Visual Analogue Scale (VAS); safety monitored for adverse events.

Main Results:

  • L-PRP demonstrated statistically significant improvement in DASH scores (functional outcome) at 6 months compared to corticosteroids.
  • Corticosteroid group showed return to baseline DASH scores, while L-PRP group maintained improved scores.
  • VAS scores indicated initial pain relief for both, with a trend towards greater L-PRP efficacy, though not statistically significant overall.

Conclusions:

  • L-PRP is a suitable treatment for lateral humeral epicondylitis, offering better functional recovery.
  • The analgesic effect of L-PRP is comparable to corticosteroids.
  • A second thawed L-PRP dose showed a slight additive benefit.

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