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Related Experiment Video

Updated: Feb 24, 2026

Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult
09:39

Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult

Published on: April 26, 2018

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Zika virus research models.

Jessica L Kublin1, James B Whitney2

  • 1Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

Virus Research
|August 17, 2017
PubMed
Summary
This summary is machine-generated.

The 2015 Zika virus outbreak revealed severe neurological defects, prompting global health concerns. This review examines various model systems developed to study Zika virus, aiding in drug and vaccine development.

Keywords:
Cell culture modelsNonhuman primate modelsTherapeuticsVaccinesZika virus

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Last Updated: Feb 24, 2026

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Area of Science:

  • Virology
  • Epidemiology
  • Neuroscience

Background:

  • The 2015 Brazilian Zika virus outbreak highlighted its link to severe neurological defects in neonates and adults, evolving from a perceived mild illness.
  • The World Health Organization declared the 2016 Zika epidemic a public health emergency, advising pregnancy deferral in affected regions.

Purpose of the Study:

  • To review and detail the diverse model systems utilized for studying Zika virus biology.
  • To support the development of targeted drugs and vaccines against Zika virus.

Main Methods:

  • This review synthesizes information from existing literature on various Zika virus model systems.
  • Focuses on models relevant to understanding Zika transmission, pathogenesis, and potential therapeutic interventions.

Main Results:

  • Multiple model systems have been established to investigate different aspects of Zika virus.
  • These models are crucial for advancing research into Zika's impact on neurological health.

Conclusions:

  • The development and application of diverse model systems are essential for comprehensive Zika virus research.
  • Continued study using these models is critical for effective control strategies and medical countermeasures against Zika virus.