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Zebrafish earns its stripes for in vivo ASC speck dynamics
Jelena S Bezbradica1, Kate Schroder2
1The Kennedy Institute of Rheumatology, University of Oxford, Oxford, England, UK jelena.bezbradica@kennedy.ox.ac.uk.
The Journal of Cell Biology
|August 17, 2017
Abstract:
Assembly of the ASC speck is critical for signaling by the inflammasome. In this issue, Kuri et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201703103) use live microscopy to track fluorescently tagged endogenous ASC in the zebrafish, describing the molecular domains driving ASC speck assembly and identifying a key role for macrophages in ASC speck removal in vivo.
