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High-performance therapeutic quercetin-doped adhesive for adhesive-dentin interfaces.

Hongye Yang1, Kang Li1, Huiyi Yan1

  • 1The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory for Oral Biomedical Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, People's Republic of China.

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Researchers developed a new therapeutic dental adhesive by adding quercetin, a plant extract, to improve restoration longevity. This quercetin-doped adhesive effectively combats bacteria and maintains bond strength, extending the life of dental work.

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Area of Science:

  • Dental Materials Science
  • Biomaterials Engineering
  • Nanotechnology

Background:

  • Dental restoration failure is a significant clinical issue, with nearly half failing within a decade.
  • Replacing failed restorations consumes substantial dental practice time, highlighting the need for improved adhesive longevity.
  • Current dentin adhesives require modification to address secondary caries and prevent degradation at the adhesive-dentin interface.

Purpose of the Study:

  • To develop a versatile therapeutic dental adhesive by incorporating quercetin into a commercial adhesive.
  • To evaluate the antibacterial properties, bonding performance, and biocompatibility of quercetin-doped adhesives.
  • To determine the optimal concentration of quercetin for enhanced adhesive functionality.

Main Methods:

  • Quercetin was incorporated into a commercial dental adhesive at concentrations of 100, 500, and 1000 µg/mL.
  • Evaluated antibacterial activity against Streptococcus mutans biofilm.
  • Assessed conversion degree, microtensile bond strength, failure modes, in situ zymography, nanoleakage, and cytotoxicity.

Main Results:

  • The quercetin-doped adhesive (500 µg/mL) demonstrated preserved bonding properties against collagenase aging.
  • Significant inhibition of Streptococcus mutans biofilm growth was observed.
  • The modified adhesive exhibited efficient interface sealing, matrix metalloproteinase inhibition, and acceptable biocompatibility.

Conclusions:

  • A simple, safe, and workable strategy was developed to create therapeutic dental adhesives.
  • Quercetin incorporation enhances adhesive properties, offering a solution to extend the service life of dental restorations.
  • The developed therapeutic adhesive shows promise in combating secondary caries and improving clinical outcomes.