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Updated: Feb 24, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
A new anthracycline-type metabolite from Streptomyces sp. NEAU-L3
Chang Lu1, Yue Zhao1, Wei-Qi Jia1
1Life Science and Biotechnology Research Center, School of Life Science, Northeast Agricultural University, Harbin, China.
Abstract:
A new anthracycline-type metabolite, designated as tetracenoquinocin A (1), was isolated from the fermentation broth of Streptomyces sp. NEAU-L3. Its structure was determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as ESI-MS and comparison with data from the literature. Compound 1 showed potent cytotoxic activity against three cancer cell lines (HepG2, A549, HCT-116) with IC50 values of 5.57, 24.30 and 20.82 μM, respectively.
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