Related Experiment Video
Updated: Feb 24, 2026
In Vitro Model of Coronary Angiogenesis
Published on: March 10, 2020
The Relationship between VEGFA and TGFB1 Polymorphisms and Target Lesion Revascularization after Elective
Tadeusz Osadnik1, Andrzej Lekston2, Kamil Bujak2
12nd Department of Cardiology and Angiology, Silesian Center for Heart Disease, Zabrze, Poland.
Background And Aim:
The specific association between genetic variation and in-stent restenosis is still only partly understood. The aim of this study is to analyze the relationship between functional polymorphisms in the genes encoding vascular endothelial growth factor A (VEGF-A; rs699947) and transforming growth factor beta 1 (TGF-β1; rs1800470) and target lesion revascularization (TLR) risk.
Methods:
A total of 676 patients (805 lesions) with stable coronary artery disease (SCAD) who received elective percutaneous coronary intervention (PCI) with at least one bare-metal stent implantation were included. The primary study endpoint was TLR at a 4-year follow-up.
Results:
The TLR rate was higher in patients with the VEGFA A/A genotype (15.4%) than in patients with the VEGFA A/C (7.9%) and C/C (8.9%) genotypes (p = 0.009). The VEGFA A/A genotype, after adjustment for clinical and procedural covariates, remained significantly and independently associated with the TLR (hazard ratio-2.09 [95% confidence interval 1.32-3.33, p = 0.0017]). However, we found no association between TLR and the TGFB1 genotype.
Conclusion:
The VEGFA A/A genotype is significantly and independently associated with TLR risk in Polish SCAD patients who received elective PCI with bare-metal stent implantation.
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