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Updated: Feb 24, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Factors associated with antibiotic prescriptions for the viral origin diseases in office-based practices, 2006-2012
Sara Imanpour1, Obioma Nwaiwu2, Darcy K McMaughan1
1Texas A&M University, College Station, TX 77843, USA.
Objective:
To test the potential association between time spent with a doctor and antibiotic overprescriptions in case of the common cold, runny nose, bronchitis, chest colds, flu, sore throats, and fluid in the middle ear.
Design:
Cross-sectional study.
Setting:
Office-based physicians in the US.
Participants:
A total of 261,623 patient visits recorded to office-based physicians in the US.
Main Outcome Measures:
The interest outcome was unnecessary antibiotic prescription.
Results:
The analysis revealed five significant predictors of antibiotic prescriptions for suspected viral infections: length of doctor-patient encounter time, patient gender, spending time with a family medicine doctor, type of insurance, and the rate of antibiotic prescriptions per physician. For every additional minute a patient spent with a physician during a visit, the mean predicted probability of receiving unnecessary antibiotics decreased by 2.4%.
Conclusions:
This study provided evidence that physicians continue to prescribe antibiotics in avoidable cases. Policies that would monitor antibiotic prescription in office-based settings should be considered in order to control spreading of antibiotic resistance and eventually improve population health.
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