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Related Concept Videos

Long-term Potentiation01:35

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
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Parkinson's Disease: Overview01:15

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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
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Long-term disability and progression in spinal onset multiple sclerosis.

Bedile Irem Tiftikcioglu1, Irem Ilgezdi2, Yasar Zorlu2

  • 1Department of Neurology, TCSB Izmir Tepecik Education and Research Hospital, Gaziler caddesi No: 468, Yenisehir, Konak, 35170, Izmir, Turkey. irem.tiftikcioglu@gmail.com.

Acta Neurologica Belgica
|August 17, 2017
PubMed
Summary

Initial spinal cord involvement in multiple sclerosis (MS) patients is linked to a more severe disease course. Early SC lesions indicate a higher risk of progression and long-term disability.

Keywords:
Initial relapseMultiple sclerosisOutcomeProgressionRecoverySpinal cord

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Area of Science:

  • Neurology
  • Immunology
  • Neuroscience

Background:

  • Multiple Sclerosis (MS) is a chronic, demyelinating disease of the central nervous system.
  • Understanding the prognostic factors influencing MS progression is crucial for patient management.
  • The impact of initial spinal cord (SC) involvement on long-term outcomes in MS remains an area of active investigation.

Purpose of the Study:

  • To investigate the long-term effects of initial spinal cord (SC) involvement in patients diagnosed with multiple sclerosis (MS).
  • To identify whether early SC lesions correlate with disease severity, progression rates, and long-term disability.
  • To explore the relationship between initial relapse recovery and subsequent disease course in MS patients.

Main Methods:

  • Retrospective, single-center study including 476 definite MS patients with complete follow-up data.
  • Data collection included demographics, initial symptoms, recovery from initial relapse, neuroimaging, CSF analysis, long-term disability, and progression.
  • Statistical analysis compared outcomes between patients with and without initial SC involvement.

Main Results:

  • 33.0% of patients experienced SC involvement during their first clinical relapse.
  • Initial SC involvement was associated with older age at disease onset (p=0.028), higher progression rates (p=0.001), and greater long-term disability (p<0.001).
  • Poor recovery from the initial relapse was linked to older onset age, higher disability scores, and increased risk for progression.

Conclusions:

  • Initial spinal cord involvement in MS patients signifies a more severe initial relapse with reduced recovery potential.
  • Early SC lesions are a significant risk factor for increased disease progression and long-term disability in MS.
  • Further validation in diverse MS cohorts is recommended to enhance understanding of these complex disease mechanisms.