Related Experiment Video
Updated: Feb 24, 2026
03:53
Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes
Published on: April 19, 2024
1.2K
The Potential for Emerging Microbiome-Mediated Therapeutics in Asthma
Ayse Bilge Ozturk1, Benjamin Arthur Turturice2, David L Perkins3,4,5
1Department of Allergy and Immunology, Koc University Hospital, Istanbul, Turkey.
Current Allergy and Asthma Reports
|August 17, 2017
Summary
The gut and lung microbiome influence asthma. While microbiome-targeted therapies show promise for asthma management, current clinical evidence is insufficient for widespread use.
Area of Science:
- Microbiome research
- Immunology
- Respiratory medicine
Background:
- The microbiome plays a crucial role in immune regulation.
- Dysbiosis in the gut and lung microbiota is linked to asthma pathogenesis.
- Innate immune molecules are key mediators in asthma.
Purpose of the Study:
- To review the literature on gut and lung microbiota in asthma.
- To focus on the role of innate molecules in asthma.
- To explore emerging microbiome-mediated therapeutics for asthma.
Main Methods:
- Literature review of recent clinical and basic studies.
- Analysis of data integrating microbiome information with technological advances.
- Focus on next-generation sequencing and omics data.
Main Results:
- Several therapeutics targeting innate immunity and the microbiome show potential for asthma.
- Some therapies demonstrate benefits in specific asthma phenotypes and early-life protection.
- Current clinical data do not yet support these therapies for effective asthma treatment.
Conclusions:
- Integrating microbiome data with advanced technologies like next-generation sequencing and omics offers significant promise.
- Future asthma treatment may be shaped by comprehensive bioinformatics, novel molecules, and innovative approaches.
- Further research is needed to validate microbiome-based therapies for asthma management.
Related Concept Videos
01:29Microorganisms in Medicine and Therapeutics
1.2K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.2K
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
2.0K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
2.0K
01:20Asthma: Pathogenesis and Management
1.5K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.5K
01:29Asthma-I: Introduction
3.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.6K
01:19Antiasthma Drugs: Leukotriene Modifiers
2.0K
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
2.0K
01:26Asthma-II: Pathophysiology and Classification
4.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.6K