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Bevacizumab in advanced lung cancer: state of the art

Sandra Assoun1, Solenn Brosseau1,2, Christelle Steinmetz3

  • 1Department of Thoracic Oncology & CIC 1425/CLIP2 Paris-Nord, Bichat-Claude Bernard Hospital, APHP, Paris, France.

Future Oncology (London, England)
|August 17, 2017
PubMed

Insights

Bevacizumab, an anti-VEGF antibody, offers a valuable combination approach for advanced lung cancer. This review details its efficacy and safety in non-small cell lung cancer (NSCLC) and small cell lung cancer.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Despite advances in lung cancer treatment, patient prognosis remains poor.
  • Combination therapies involving established drugs like bevacizumab are crucial.

Purpose of the Study:

  • To review the pharmacologic properties, clinical efficacy, and safety of bevacizumab in advanced lung cancer.
  • To explore bevacizumab's potential in combination with novel therapies for improved outcomes.

Main Methods:

  • Literature review of bevacizumab's use in advanced non-small cell lung cancer (NSCLC), EGFR-mutant NSCLC, and small-cell lung cancer.
  • Analysis of clinical trial data and pharmacologic properties.

Main Results:

  • Bevacizumab is approved for advanced non-squamous NSCLC in combination with chemotherapy.
  • The review synthesizes data on its efficacy and safety profile.

Conclusions:

  • Bevacizumab remains a relevant therapeutic option for advanced lung cancer.
  • Future research should focus on combining bevacizumab with newer molecular and immuno-oncology agents to enhance treatment efficacy and overcome resistance.
Keywords:
angiogenesis inhibitorbevacizumablung cancer

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