Related Experiment Video

Updated: Feb 24, 2026

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

9.4K

Rotavirus disease course among immunocompromised patients; 5-year observations from a tertiary care medical centre

P Bruijning-Verhagen1, M D Nipshagen2, H de Graaf3

  • 1Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Huispostnummer STR.6.131, Postbus 85500, 3508 GA Utrecht, The Netherlands.

The Journal of Infection
|August 17, 2017
PubMed

Insights

Rotavirus gastroenteritis (RVGE) is severe in immunocompromised patients, often requiring disease management changes. Routine rotavirus testing is recommended for these individuals with suspected gastroenteritis.

Area of Science:

  • Infectious Diseases
  • Gastroenterology
  • Immunology

Background:

  • Rotavirus (RV) is a common cause of gastroenteritis, posing significant risks to immunocompromised individuals.
  • Disease severity and outcomes of rotavirus gastroenteritis (RVGE) in immunocompromised populations are not well-characterized.
  • Rotavirus testing is not standard practice for immunocompromised patients beyond infancy.

Purpose of the Study:

  • To assess the severity and characteristics of rotavirus disease in immunocompromised hospitalized patients.
  • To determine if immunocompromised status predisposes individuals to RVGE.
  • To evaluate rotavirus testing practices in a hospital setting.

Main Methods:

  • Retrospective analysis of 5-year laboratory records for rotavirus infections.
  • Chart review to evaluate disease course in immunocompromised patients.
  • Matched case-control analysis comparing immunocompromised and non-immunocompromised patients.
  • Assessment of rotavirus testing rates over a 3-year period.

Main Results:

  • Immunocompromised patients constituted a significant proportion of adult (57%) and pediatric (12%) RVGE cases.
  • A complicated disease course occurred in 81% of immunocompromised patients, with 33% requiring management adaptations.
  • Immunocompromised adults were 7.4 times more likely to develop RVGE than controls.
  • Rotavirus testing was infrequent (12%) in adult patients with suspected infectious gastroenteritis.

Conclusions:

  • Adult immunocompromised patients represent the majority of RVGE cases in a hospital setting.
  • RVGE in immunocompromised individuals is linked to substantial morbidity and impacts underlying disease management.
  • Routine rotavirus testing should be considered for immunocompromised patients presenting with suspected infectious gastroenteritis.

Keywords:
ComplicationsHospitalImmunocompromisedInfectious gastroenteritisNosocomialRotavirusVaccination

More Related Videos

An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay09:14

An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay

Published on: January 26, 2019

11.6K
An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

8.4K

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
6.5K
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
352
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
2.6K
Pathophysiology of Vomiting01:22

Pathophysiology of Vomiting

Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
3.4K
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
830
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
862