We Can Still Be Friends: IFN-γ Breaks Up Macrophage Enhancers
Boris Novakovic1, Cheng Wang1, Colin Logie1
1Department of Molecular Biology, Radboud Institute of Molecular Life Sciences and Faculty of Science, Radboud University, 6525 GA Nijmegen, the Netherlands.
Immunity
|August 17, 2017
Abstract:
Interferon (IFN)-γ can prime macrophages for inflammatory responses by several mechanisms, including enhancer establishment and gene activation. In this issue of Immunity, Kang et al. (2017) provide insight into the mechanisms of IFN-γ-mediated gene repression as they show that IFN-γ promotes the disassembly of select active enhancers by interfering with enhancer-binding transcription factor MAF.
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