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Disseminated Blastomycosis Mimicking Malignancy.

Jennifer L Hsu^1,2, B Joel Tjarks^3,4, Aaron Berg^5,4

¹Department of Internal Medicine, University of South Dakota Sanford School of Medicine.

South Dakota Medicine : the Journal of the South Dakota State Medical Association

|August 17, 2017

Summary

This summary is machine-generated.

Disseminated blastomycosis, a fungal infection, can mimic cancer and spread to multiple organs. This case highlights the challenges in diagnosing and treating this severe condition, even with aggressive amphotericin B therapy.

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Area of Science:

Mycology
Infectious Diseases
Medical Case Reports

Background:

Blastomycosis is an endemic fungal infection caused by Blastomyces dermatitidis, primarily affecting the Mississippi and Ohio River basins and the Great Lakes region.
While typically presenting as pneumonia, Blastomyces dermatitidis can disseminate hematogenously to multiple organs.

Observation:

A 57-year-old male in South Dakota developed disseminated blastomycosis.
The patient presented with involvement of the brain, lungs, adrenal glands, and testes.
Diagnostic evaluation was complicated by suspicion of malignancy due to widespread organ involvement.

Findings:

The disseminated blastomycosis mimicked malignancy, posing diagnostic challenges.
Despite treatment with amphotericin B, the patient's condition was fatal.

Implications:

This case underscores the importance of considering endemic fungal infections like blastomycosis in differential diagnoses, especially when clinical presentations are atypical or mimic other serious diseases.
Early and accurate diagnosis is crucial for effective management of disseminated blastomycosis.
The case highlights the potential severity and poor prognosis of disseminated blastomycosis, even with aggressive treatment.