Organisation of collagen fibrils in tendon: changes induced by an anabolic steroid. II. A morphometric and stereologic analysis

Morphometric and stereologic analysis of the organisation of collagen fibrils in tendon tissue after a treatment with an anabolic steroid hormone allowed the following observations: In a short-term study stereological data revealed a potent accumulation of collagen fibrils in the extra-cellular matrix after the administration of an anabolic steroid. Compared with controls, the anabolic steroid significantly increased the number of dysplastic collagen fibrils dependent on duration of treatment. Inter- and intrafibrillary dysplastic collagen fibrils possess characteristic diameter distributions which differ considerably from those of normal collagen fibrils. The functional significance of the changes in mean diameter, diameter distribution, numerical density and volume fraction of collagen fibrils in tendons following hormone treatment may be relevant to the use of these drugs in clinical practice and in competitive sports.