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Plasma nesfatin 1 level in patients with first attack psychosis
Bratislavske Lekarske Listy
|August 18, 2017
Summary
This study explored nesfatin-1 levels in first-episode psychosis patients, finding no significant difference compared to healthy controls. Further research is needed to confirm nesfatin-1
Area of Science:
- Neuroscience
- Psychiatry
- Biochemistry
Background:
- Nesfatin-1 is an endogenous peptide with potential roles in the central nervous system.
- Altered neuropeptide levels are implicated in the pathophysiology of psychotic disorders.
Purpose of the Study:
- To investigate the relationship between plasma nesfatin-1 concentrations and first-episode psychosis.
- To explore potential correlations between nesfatin-1 levels and symptom severity in patients with first-episode psychosis.
Main Methods:
- A case-control study involving 32 patients with first-episode psychosis and 33 healthy controls.
- Plasma nesfatin-1 levels were measured using the enzyme-linked immunosorbent assay (ELISA) method.
- Symptom severity was assessed using the Positive and Negative Syndrome Scale (PANNS).
Main Results:
- Mean plasma nesfatin-1 levels were not significantly different between patients with first-episode psychosis and healthy controls (p = 0.573).
- No statistically significant correlation was found between plasma nesfatin-1 levels and total PANNS scores in the patient group (p = 0.148).
Conclusions:
- This is the first study to examine nesfatin-1 levels in first-episode psychosis.
- Nesfatin-1 may be associated with central nervous system pathologies and psychiatric disorder severity, but further large-scale studies are required.
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