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Hybrid core shell nanoparticles entrapping Gd-DTPA and 18F-FDG for simultaneous PET/MRI acquisitions
Donatella Vecchione1,2, Marco Aiello3, Carlo Cavaliere3
1Istituto Italiano di Tecnologia, Center for Advanced Biomaterials for Health Care IIT@CRIB, Largo Barsanti e Matteucci 53, 80125 Naples, Italy.
Aim:
Although there has been an improvement in the hardware and software of the PET/MRI system, the development of the nanoprobes exploiting the simultaneous acquisition of the bimodal data is still under investigation. Moreover, few studies on biocompatible and clinically relevant probes are available. This work presents a core-shell polymeric nanocarrier with improved relaxometric properties for simultaneous PET/MRI acquisitions.
Materials & Methods:
Core-shell nanoparticles entrapping the Gd-DTPA and 18F-FDG are obtained by a complex coacervation.
Results & Discussion:
The boosting of r1 of the entrapped Gd-DTPA up to five-times compared with 'free Gd-DTPA', is confirmed by the PET/MRI scan. The sorption of 18F-FDG into the nanoparticles is studied and designed to be integrated downstream for the production of the tracer.
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