Alterations in resting-state functional connectivity of the default mode network in amnestic mild cognitive
Moyi Li1,2, Guohua Zheng3, Yuhui Zheng2
1Department of Rehabilitation, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, China.
Background:
Amnestic mild cognitive impairment (aMCI) is characterized by cognitive functional decline, especially in memory. Resting-state functional magnetic resonance imaging (fMRI) has been widely used in neuroimaging studies that explore alterations between patients and normal individuals to elucidate the pathological mechanisms of different diseases. The current study was performed to investigate alterations in the functional connectivity of the default mode network (DMN) in aMCI patients compared to healthy elderly controls, as well as further define the association between neurological alterations and memory function.
Methods:
Twenty-five aMCI patients and 25 healthy individuals were recruited and underwent both fMRI and neuropsychological examinations. fMRI data was analyzed by independent component analysis.
Results:
Compared to healthy individuals, aMCI patients exhibited a significant increase in functional connectivity between the DMN and right-middle and right-superior frontal gyri, left-middle occipital gyrus, and left-middle temporal gyrus, but reduced functional connectivity between the DMN and left-middle and left-inferior frontal gyri and left insula. These alterations were found to be associated with reduced memory function.
Conclusions:
aMCI patients exhibited abnormal functional connectivity between the DMN and certain brain regions which is associated with changes in memory function associated with aMCI.
Insights
Amnestic mild cognitive impairment (aMCI) shows altered brain connectivity within the default mode network (DMN). These default mode network changes in aMCI patients are linked to memory decline.
Area of Science:
- Neuroimaging
- Cognitive Neuroscience
- Neurology
Background:
- Amnestic mild cognitive impairment (aMCI) involves memory decline.
- Resting-state fMRI is crucial for studying brain alterations in diseases.
- Understanding default mode network (DMN) changes is key to aMCI pathology.
Purpose of the Study:
- Investigate DMN functional connectivity alterations in aMCI patients versus healthy controls.
- Determine the association between these neurological changes and memory function in aMCI.
Main Methods:
- Recruited 25 aMCI patients and 25 healthy elderly controls.
- Utilized resting-state functional magnetic resonance imaging (fMRI).
- Analyzed fMRI data using independent component analysis.
Main Results:
- aMCI patients showed increased DMN connectivity with right frontal, left occipital, and left temporal gyri.
- Reduced DMN connectivity was observed in aMCI patients within left frontal gyri and the insula.
- These connectivity alterations correlated with diminished memory function.
Conclusions:
- aMCI patients exhibit abnormal DMN functional connectivity.
- These brain connectivity changes are associated with memory impairments characteristic of aMCI.
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