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Cesarean Delivery and Body Mass Index at 6 Months and Into Childhood
Rebecca Kofod Vinding1,2, Tobias Steen Sejersen1,2, Bo L Chawes1
1Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health and Medical Sciences, University of Copenhagen and Danish Pediatric Asthma Center, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Insights
Cesarean delivery (CD) was associated with higher BMI in infants at 6 months. However, this difference in childhood obesity did not persist into later childhood, suggesting CD does not lead to long-term overweight.
Area of Science:
- Pediatric Health
- Obstetrics
- Growth and Development
Background:
- Rising rates of cesarean delivery (CD) and childhood obesity worldwide.
- Previous studies suggest a potential association between CD and increased childhood obesity risk.
Purpose of the Study:
- To investigate the association between cesarean delivery and body mass index (BMI) development from birth through childhood.
- To determine if CD influences long-term growth trajectories and obesity risk.
Main Methods:
- Prospective birth cohort study (COPSAC2000 and COPSAC2010) including term infants.
- Regular height, length, and weight measurements until 13 years.
- Dual-energy X-ray absorptiometry (DXA) scans at 3.5 and 7 years.
- Statistical analyses adjusted for relevant covariates.
Main Results:
- Children born via CD showed a higher mean BMI at 6 months (meta-analysis: β=0.37, P=0.002).
- No significant differences in BMI trajectory or cross-sectional BMI were observed at 5 or 13 years between CD and vaginal delivery groups.
- Fat percentage measurements from DXA scans also showed no differences between groups.
Conclusions:
- Cesarean delivery is linked to a transient increase in infant BMI at 6 months.
- This early difference in BMI does not predict later childhood overweight or obesity.
- The study does not support a causal link between cesarean delivery and long-term obesity.
Background And Objectives:
The prevalence of cesarean delivery (CD) is rising worldwide, and so is childhood obesity. Studies have shown associations between these factors. We examined the development of BMI from birth through childhood to determine whether CDs were associated with differences in growth and obesity.
Methods:
Term children from the birth cohorts Copenhagen Prospective Studies on Asthma in Childhood2000 (COPSAC2000) and COPSAC2010 were included. Height, length, and weight measurements were collected prospectively until 5 years in COPSAC2010 and until 13 years in COPSAC2000. Dual-energy x-ray absorptiometry (DXA) scans were performed at 3.5 and 7 years. Information on relevant covariates were verified during clinical visits. Analyses were adjusted for covariates associating with CD.
Results:
In COPSAC2010, 20% (N = 138/673) of the children were delivered by CD; 49% were girls. In COPSAC2000, 19% (N = 76/393) were delivered by CD; 51% were girls. Children delivered by CD had a higher mean BMI at 6 months compared with those delivered vaginally: COPSAC2010 β-coefficient, .41 (95% confidence interval [CI], .12 to .69), P = .01; COPSAC2000 β-coefficient, .16 (95% CI, -.11 to .68), P = .16; and meta-analysis β-coefficient, .37 (95% CI, .14 to .60), P = .002. There were no differences in BMI trajectory between the 2 groups by 5 and 13 years, nor cross-sectional BMI at 5 and 13 years, nor in fat percentages from DXA scans.
Conclusions:
Children delivered by CD had a higher BMI at 6 months of age, but this difference did not track into later childhood. Our study does not support the hypothesis that CD leads to later overweight.
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