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Platelet distribution width as a prognostic factor in patients with COPD - pilot study.

Adam J Białas1,2, Claudio Pedone3, Wojciech J Piotrowski1,2

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PubMed
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Elevated platelet distribution width (PDW) is linked to poorer survival in chronic obstructive pulmonary disease (COPD) patients. This finding suggests PDW could be a valuable prognostic marker for COPD.

Keywords:
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Area of Science:

  • Pulmonary Medicine
  • Hematology
  • Critical Care Medicine

Background:

  • Platelets are implicated in COPD inflammation.
  • Platelet distribution width (PDW) may indicate platelet activation.
  • Hypercoagulation is associated with worse COPD outcomes.

Purpose of the Study:

  • To investigate the association between PDW and survival in COPD patients.
  • To explore PDW as a potential marker for hypercoagulation in COPD.

Main Methods:

  • Retrospective analysis of 79 COPD patients.
  • Grouped patients based on upper normal PDW limit.
  • Compared survival using Kaplan-Meier and Cox regression.

Main Results:

  • Elevated PDW associated with reduced lung function (FEF 25-75, PEF).
  • Median survival was significantly lower for patients with elevated PDW (743 vs 1,305 days).
  • Adjusted Hazard Ratio for mortality was 4.59 in the elevated PDW group.

Conclusions:

  • Elevated PDW is associated with reduced survival in COPD.
  • PDW may serve as an inexpensive prognostic tool for COPD.