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Diabetic retinopathy: reversibility of epigenetic modifications and new therapeutic targets

Xinyuan Zhang1, Lin Zhao1, Brett Hambly2

  • 1Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Tongren Hospital, Beijing Ophthalmology & Visual Sciences Key Lab, Capital Medical University, Beijing, 100730 People's Republic of China.

Cell & Bioscience
|August 18, 2017
PubMed

Insights

Epigenetic modifications, which are reversible, offer new therapeutic strategies for diseases. This review highlights their potential in treating diabetic retinopathy (DR) and related complications.

Area of Science:

  • Molecular mechanisms of epigenetics
  • Disease development and progression
  • Epigenetic modifications in disease treatment

Background:

  • Diabetic retinopathy (DR) pathogenesis is not fully understood.
  • Refractory and recurrent diabetic macular edema present clinical challenges.
  • Epigenetic modifications are increasingly recognized for their role in disease.

Purpose of the Study:

  • To review the role of epigenetic modifications in disease.
  • To emphasize the therapeutic potential of reversible epigenetic changes.
  • To explore epigenetic strategies for preventing and treating diseases like diabetic retinopathy.

Main Methods:

  • Literature review of recent advancements in epigenetics and disease.
  • Analysis of the reversibility of epigenetic modifications.
  • Focus on the application of epigenetic insights to diabetic retinopathy treatment.

Main Results:

  • Epigenetic modifications play a significant role in disease development and progression.
  • The reversible nature of epigenetic changes offers novel therapeutic avenues.
  • Epigenetic strategies show promise for managing complex conditions like diabetic retinopathy.

Conclusions:

  • Reversible epigenetic modifications represent a promising new strategy for disease prevention and treatment.
  • Further research into epigenetic mechanisms could lead to breakthroughs in managing diseases such as diabetic retinopathy.
  • Targeting epigenetic alterations may provide solutions for refractory conditions like diabetic macular edema.
Keywords:
Chromatin remodelingDNA methylationDiabetic retinopathyEpigenetic modificationsGeneHistone modificationNon-coding RNATherapeutic target

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