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Updated: Feb 24, 2026

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
Published on: June 12, 2021
"UPRegulation" of CD47 by the endoplasmic reticulum stress pathway controls anti-tumor immune responses
Katherine L Cook1,2,3, David R Soto-Pantoja1,2,4,3
1Department of Surgery, Wake Forest School of Medicine, Winston-Salem, NC 27157 USA.
Abstract:
We recently demonstrated that targeting the unfolded protein response (UPR) protein GRP78 down-regulates CD47 expression, resulting in increased tumor macrophage infiltration and inhibited resistance to anti-estrogen therapy. We now show new data indicating that anti-estrogen therapy regulates CD47 expression and implicates its ligand, thrombospondin-1, in regulation of tumor macrophage infiltration. Moreover, GRP78 and CD47 co-expression is associated with poor prognosis in breast cancer patients, suggesting the existence of crosstalk between UPR and immunity that regulates therapeutic responses in breast cancer.
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