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Updated: Feb 24, 2026

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model

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Published on: December 10, 2021

"Spice" (Synthetic Marijuana) Induced Acute Myocardial Infarction: A Case Series.

E Ul Haq¹, A Shafiq², A A Khan³

¹University of South Alabama, Mobile, AL, USA.

Case Reports in Cardiology

|August 18, 2017

Summary

Synthetic marijuana, or "Spice," can cause acute myocardial infarction (AMI) in young adults. This case series highlights the need to consider synthetic marijuana use in young patients presenting with AMI, even with no traditional risk factors.

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Area of Science:

Cardiology
Toxicology
Emergency Medicine

Background:

Marijuana is a widely used recreational substance associated with various health issues.
While marijuana can cause coronary vasospasm, a direct link to acute myocardial infarction (AMI) is not well-established.
Spice, a synthetic marijuana, mimics marijuana's effects and is increasingly prevalent.

Observation:

This report details three cases of young adults experiencing ST-segment elevation myocardial infarction (STEMI).
All patients had minimal to no cardiovascular disease risk factors.
The patients presented with symptoms indicative of AMI, prompting emergent coronary angiography.

Findings:

All three cases were linked to the use of synthetic marijuana (Spice).
Two patients required stent placement, and one underwent aspiration thrombectomy.
The findings suggest a causal relationship between Spice use and AMI in young individuals.

Implications:

Clinicians should consider synthetic marijuana use in the differential diagnosis for young adults presenting with AMI.
Investigating synthetic marijuana use is crucial for appropriate patient management and risk assessment.
This underscores the potential cardiovascular risks associated with novel psychoactive substances.