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D2Refine: A Platform for Clinical Research Study Data Element Harmonization and Standardization.

Deepak K Sharma1, Harold R Solbrig1, Eric Prud'hommeaux2

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Summary
This summary is machine-generated.

D2Refine harmonizes and standardizes clinical research data elements using OpenRefine and CTS2 standards. This platform enhances data organization and semantic interoperability for research studies.

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Area of Science:

  • Biomedical Informatics
  • Clinical Research Informatics

Background:

  • Clinical research data often lacks standardization, hindering data sharing and analysis.
  • Harmonizing data elements is crucial for interoperability and efficient research.

Purpose of the Study:

  • To introduce D2Refine, a platform for clinical research data element harmonization and standardization.
  • To leverage OpenRefine's capabilities with CTS2 standards for improved data management.

Main Methods:

  • Developed D2Refine on OpenRefine, incorporating reconciliation services.
  • Implemented CTS2-based search and serialization for data element definitions.
  • Utilized clinical information modeling for semantic interoperability.

Main Results:

  • D2Refine effectively organizes and standardizes clinical research data elements.
  • The platform facilitates rapid transformation of source data sets.
  • Demonstrated improved semantic interoperability through standard representations.

Conclusions:

  • D2Refine is a promising platform for addressing clinical research data harmonization needs.
  • The tool enhances data quality and facilitates research study efficiency.
  • Promotes better data management and interoperability in clinical research.