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Updated: Feb 24, 2026
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Published on: August 15, 2025
Elimination of medically intractable epileptic drop attacks following endoscopic total corpus callosotomy in Rett
Keisuke Ueda1,2, Sandeep Sood2,3, Eishi Asano1,2
1Division of Neurology, Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI, 48201, USA.
Introduction:
Rett syndrome is a neurodevelopmental genetic disorder, characterized by developmental delay, hand stereotypies, abnormal gait, and acquired microcephaly. Epilepsy is very common in Rett syndrome and can be medically intractable. It remains uncertain if a patient with epileptic drop attacks associated with this genetic disease can benefit from corpus callosotomy.
Case Report:
We report an 8-year-old girl with Rett syndrome and medically intractable epileptic drop attacks who underwent endoscopic total corpus callosotomy without any complications that led to the successful elimination of her seizures.
Conclusion:
Total corpus callosotomy is a feasible treatment option for medically intractable epileptic drop attacks in Rett syndrome and should not be considered as a contraindication in this condition. This is the first reported case of corpus callosotomy in Rett syndrome.
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