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Emerging roles of rhomboid-like pseudoproteases in inflammatory and innate immune responses

Wei-Wei Luo1, Hong-Bing Shu2

  • 1Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.

FEBS Letters
|August 18, 2017
PubMed

Insights

iRhom2, a pseudoprotease, regulates innate immunity by controlling MITA (STING) protein stability and trafficking. This protein is linked to inflammatory diseases and innate antiviral responses.

Area of Science:

  • Molecular Biology
  • Immunology
  • Cell Biology

Background:

  • Rhomboid-like pseudoproteases are related to serine proteases but lack catalytic activity.
  • iRhom2, a pseudoprotease, influences ADAM17 processing and is implicated in inflammatory arthritis.
  • Emerging evidence links iRhom2 to innate immunity pathways.

Purpose of the Study:

  • To summarize recent findings on the roles and mechanisms of iRhom2 and its homologs in innate immunity.
  • To discuss the connection between iRhom functions and immunological diseases.

Main Methods:

  • Literature review of recent studies on iRhom2.
  • Analysis of iRhom2's role in protein trafficking and stability.
  • Exploration of iRhom2's involvement in innate immune signaling pathways.

Main Results:

  • iRhom2 regulates the trafficking and stability of MITA (STING), a key innate antiviral signaling adaptor.
  • iRhom2's functions extend beyond ADAM17 regulation into innate immune responses.
  • Dysregulation of iRhom proteins is associated with immunological diseases.

Conclusions:

  • iRhom2 plays a critical role in innate immunity by modulating MITA/STING.
  • Understanding iRhom functions provides insights into the pathogenesis of immunological diseases.
  • Further research into iRhoms could reveal new therapeutic targets for immune disorders.
Keywords:
inflammatory responsesinnate immunityrhomboid-like pseudoprotease

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