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The silent enemy: Celiac disease goes viral
Alberto Reale1, Marta Trevisan1, Gualtiero Alvisi1
1Department of Molecular Medicine, University of Padua, Padua, Italy.
Journal of Cellular Physiology
|August 18, 2017
Summary
Celiac disease, an autoimmune disorder, may be triggered by intestinal infections from common reoviruses. This study links these viral infections to the onset of celiac disease in susceptible individuals.
Area of Science:
- Gastroenterology
- Immunology
- Virology
Background:
- Celiac disease is a chronic inflammatory autoimmune disorder affecting 1% of the global population.
- Gluten ingestion in susceptible individuals triggers small intestine mucosal damage.
- The onset of celiac disease is linked to external triggers, possibly viral infections.
Purpose of the Study:
- To investigate the potential role of viral infections in the onset of celiac disease.
- To explore the mechanistic link between reoviruses and celiac disease development.
Main Methods:
- The study examined the association between intestinal infections and celiac disease.
- Focus was placed on common reoviruses as a potential trigger.
- Mechanistic pathways were investigated.
Main Results:
- A surprising link was discovered between intestinal reovirus infections and the onset of celiac disease.
- Evidence suggests a mechanistic basis for viral triggers in celiac disease.
Conclusions:
- Common reoviruses may act as an external trigger for celiac disease in genetically predisposed individuals.
- Further research is warranted to fully elucidate the role of viral infections in celiac disease pathogenesis.
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