Direct and Stereospecific [3+2] Synthesis of Pyrrolidines from Simple Unactivated Alkenes
Jorge Otero-Fraga1, Samuel Suárez-Pantiga1, Marc Montesinos-Magraner1
1Department of Organic Chemistry and the Berzelii EXSELENT Center for Porous Materials, Stockholm University, Arrhenius Laboratory, 106 91, Stockholm, Sweden.
Abstract:
Pyrrolidines are important heterocyclic compounds with endless applications in organic synthesis, metal catalysis, and organocatalysis. Their potential as ligands for first-row transition-metal catalysts inspired a new method to access complex poly-heterocyclic pyrrolidines in one step from available materials. This fundamental step forward is based on the discovery of an essential organoaluminum promoter that engages unactivated and electron-rich olefins in intermolecular [3+2] cycloadditions.
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