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miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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Implications of Bcl-2 and its interplay with other molecules and signaling pathways in prostate cancer progression

Ju-Ha Kim1, Hyemin Lee1, Eun Ah Shin1

  • 1a Cancer Molecular Targeted Herbal Research Center, College of Korean Medicine , Kyung Hee University , Seoul , South Korea.

Expert Opinion on Therapeutic Targets
|August 18, 2017
PubMed
Abstract

Insights

B cell lymphoma gene 2 (BCL-2) is crucial in prostate cancer progression, particularly in androgen-independent prostate cancer (AIPC). Further research into BCL-2 molecular networks and targeted therapies is essential for effective treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Prostate cancer progression involves genetic alterations, with B cell lymphoma gene 2 (BCL-2) emerging as a key molecule.
  • The precise role of BCL-2 in prostate cancer, especially androgen-independent prostate cancer (AIPC), remains incompletely understood.
  • Androgen ablation or castration can lead to AIPC, highlighting the need to understand BCL-2's function in this context.

Purpose of the Study:

  • To review the critical role of BCL-2 in prostate cancer carcinogenesis.
  • To discuss experimental evidence on BCL-2 molecular networks in both androgen-dependent prostate cancer (ADPC) and AIPC.
  • To propose future research directions for targeting BCL-2 in prostate cancer therapy.

Main Methods:

  • Literature review focusing on BCL-2's molecular implications.
  • Analysis of BCL-2's association with other molecules and signaling pathways in prostate cancer.
  • Synthesis of experimental evidence regarding BCL-2 in ADPC and AIPC.

Main Results:

  • BCL-2 plays a more significant role in AIPC progression than in ADPC, as androgens can repress BCL-2.
  • In ADPC, BCL-2 acts as a pro-survival molecule linked to androgen-related signaling.
  • In AIPC, BCL-2 upregulation, PTEN loss, PI3K/AKT phosphorylation, and receptor tyrosine kinase (RTK) activation are key factors.

Conclusions:

  • BCL-2 is a pivotal molecule in prostate cancer progression, with distinct roles in ADPC and AIPC.
  • Understanding BCL-2's molecular networks is crucial for developing effective therapies.
  • Multi-target therapies involving BCL-2 inhibitors and related signaling pathways are recommended for future prostate cancer treatment strategies.
Keywords:
AKTBCL-2PTENandrogenmicroRNAsprostate cancer

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