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Behcet's disease and pregnancy: what to expect?
Gokcen Orgul1, Fatih Aktoz2, Mehmet Sinan Beksac1
1a Faculty of Medicine, Department of Obstetrics and Gynecology, Division of Perinatology , Hacettepe University , Ankara , Turkey.
Pregnancy in Behcet's disease (BD) patients can increase obstetric risks, especially if the disease is active. Treatment with colchicine during pregnancy was linked to higher rates of preterm labor and low birthweight.
Area of Science:
- Rheumatology
- Obstetrics
- Genetics
Background:
- Limited data exists on Behcet's disease (BD) and pregnancy outcomes.
- Conflicting reports highlight the need for further investigation into BD's impact on gestation.
Purpose of the Study:
- To analyze obstetric complications in women with Behcet's disease.
- To investigate the influence of disease activity and colchicine treatment on pregnancy outcomes in BD patients.
Main Methods:
- Retrospective analysis of 66 pregnancies in 26 women diagnosed with Behcet's disease.
- Data collected included disease activity, treatment, obstetric history, complications, and neonatal outcomes.
Main Results:
- High rates of miscarriage (24.2%) and intrauterine death (3%) were observed.
- Preterm labor (24%) and low birthweight were more frequent in patients using colchicine.
- Most pregnancies (90.9%) occurred during BD remission, with flares in only six cases.
Conclusions:
- Behcet's disease patients experiencing active symptoms during pregnancy face elevated risks of obstetric complications.
- Active BD and colchicine use during pregnancy are associated with increased risks of preterm delivery and low birthweight.
- Clinicians should be aware of these heightened risks for improved patient management.
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