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Related Experiment Video

Updated: Feb 24, 2026

Three-Dimensional Reconstruction of Orbital Fractures

Three-Dimensional Reconstruction of Orbital Fractures

Published on: May 16, 2025

Acute Sickle Cell Orbitopathy Masquerading as Orbital Cellulitis.

Christopher M Stewart¹, Zuzana Sipkova, Goran D Hildebrand

¹Oxford Eye Hospital, John Radcliffe Hospital, Headley Way, Headington, UK.

Journal of Pediatric Hematology/Oncology

|August 18, 2017

Summary

Sickle cell orbitopathy can mimic orbital cellulitis in children. Early recognition of this rare sickle cell crisis complication is crucial for timely and effective treatment, preventing misdiagnosis.

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Area of Science:

Ophthalmology
Pediatrics
Hematology

Background:

Sickle cell disease is a genetic blood disorder.
Sickle cell crisis can lead to various complications.
Orbital complications are rare but serious.

Observation:

A child presented with symptoms mimicking orbital cellulitis.
Radiological findings suggestive of sickle cell orbitopathy were initially missed.
The patient received treatment for orbital cellulitis, delaying correct diagnosis.

Findings:

Sickle cell orbitopathy is a rare but critical manifestation of sickle cell crisis.
It presents with clinical and radiological features similar to orbital cellulitis.
Delayed diagnosis can result from overlooking subtle signs.

Implications:

Considering sickle cell orbitopathy in the differential diagnosis of periorbital swelling in children with sickle cell disease is vital.
Prompt and accurate diagnosis leads to appropriate management.
Correct treatment generally results in favorable outcomes, avoiding adverse effects.