Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effective response to intravitreal faricimab in a patient with myopic neovascular membrane resistant to aflibercept.

Digital journal of ophthalmology : DJO·2026
Same author

Ethical Considerations in Transcranial Focused Ultrasound Neuromodulation for Disorders of Consciousness.

Neuromodulation : journal of the International Neuromodulation Society·2026
Same author

Common Consent Elements for Research Involving Persons with Disorders of Consciousness (CCE-DOC).

Neurocritical care·2026
Same author

Resting-state EEG for continuous prognostic monitoring and prediction of coma recovery after acute brain injury.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026
Same author

Covert brain complexity in the intensive care unit.

Cortex; a journal devoted to the study of the nervous system and behavior·2026
Same author

Safeguarding Neural Data.

Neurology·2026

Related Experiment Video

Updated: Feb 24, 2026

Engineering Transplantation-suitable Retinal Pigment Epithelium Tissue Derived from Human Embryonic Stem Cells
07:48

Engineering Transplantation-suitable Retinal Pigment Epithelium Tissue Derived from Human Embryonic Stem Cells

Published on: September 6, 2018

8.1K

Advances in Retinal Tissue Engineering.

Matthew Trese1,2, Caio V Regatieri3,4, Michael J Young5

  • 1Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA. mtrese13@gmail.com.

Materials (Basel, Switzerland)
|August 18, 2017
PubMed
Summary
This summary is machine-generated.

Regenerating the retina using cell transplantation shows promise for vision loss. Current methods face challenges with cell delivery and integration, necessitating advanced tissue engineering approaches for better outcomes.

Keywords:
poly( glycerol-sebacate) (PGS)poly(caprolactone) (PCL)poly(lactic acid) (PLLA)poly(lactic-co-glycolic acid) (PLGA)retinal engineering

More Related Videos

Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model
07:43

Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model

Published on: August 5, 2021

2.4K
A Step by Step Protocol for Subretinal Surgery in Rabbits
12:31

A Step by Step Protocol for Subretinal Surgery in Rabbits

Published on: September 13, 2016

16.1K

Related Experiment Videos

Last Updated: Feb 24, 2026

Engineering Transplantation-suitable Retinal Pigment Epithelium Tissue Derived from Human Embryonic Stem Cells
07:48

Engineering Transplantation-suitable Retinal Pigment Epithelium Tissue Derived from Human Embryonic Stem Cells

Published on: September 6, 2018

8.1K
Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model
07:43

Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model

Published on: August 5, 2021

2.4K
A Step by Step Protocol for Subretinal Surgery in Rabbits
12:31

A Step by Step Protocol for Subretinal Surgery in Rabbits

Published on: September 13, 2016

16.1K

Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Biomaterials Science

Background:

  • Retinal degenerations cause irreversible vision loss globally.
  • Existing treatments like gene therapy offer limited efficacy, merely delaying disease progression.
  • Cell transplantation is a promising strategy for retinal regeneration.

Purpose of the Study:

  • To review the evolution of retinal tissue engineering for treating retinal degenerations.
  • To highlight the role of polymeric biomaterials in recent retinal transplantation studies.
  • To identify future needs in materials and fabrication for optimizing retinal cell delivery and integration.

Main Methods:

  • Review of existing literature on retinal tissue engineering and cell transplantation.
  • Emphasis on the types of polymers used in recent retinal tissue engineering investigations.
  • Analysis of challenges and advancements in donor cell delivery and integration techniques.

Main Results:

  • Early cell transplantation studies utilized bolus injections, leading to poorly localized grafts.
  • Polymeric tissue engineering approaches have emerged, drawing parallels with other tissue regeneration fields.
  • Current methods require optimization for enhanced cell survival, differentiation, and targeted delivery.

Conclusions:

  • Retinal tissue engineering offers a pathway to restore vision lost to degeneration.
  • Advancements in polymer science and fabrication techniques are crucial for successful retinal transplantation.
  • Future research must focus on novel materials and methods to improve the efficacy of retinal cell therapies.