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Comprehensive analysis of long noncoding RNA-mRNA co-expression patterns in thyroid cancer

Yaying Du1, Wenfei Xia, Jinjun Zhang

  • 1Department of Thyroid and Breast Surgery, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430030, P. R. China. yangzhifangtj@163.com lixingrui@tjh.tjmu.edu.cn.

Molecular Biosystems
|August 18, 2017
PubMed

Insights

This study identifies novel long noncoding RNAs (lncRNAs) and messenger RNAs (mRNAs) differentially expressed in papillary thyroid cancer (PTC). These findings offer new insights into lncRNA roles in PTC progression and potential therapeutic targets.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Novel molecular-targeted treatments are promising for radioiodine-refractory and inoperable thyroid carcinomas.
  • The role of oncogenes in long noncoding RNA (lncRNA) expression in thyroid cancer remains largely uncharacterized.

Purpose of the Study:

  • To identify expression patterns of lncRNAs and mRNAs in papillary thyroid cancer (PTC).
  • To investigate the potential roles of lncRNAs in PTC progression and tumorigenesis.

Main Methods:

  • High-throughput molecular profiling of 18 PTC patients.
  • Differential expression analysis of lncRNAs and mRNAs.
  • lncRNA-mRNA co-expression network construction and analysis.
  • Validation of candidate lncRNAs in 45 PTC patients.

Main Results:

  • Identified 452 differentially expressed mRNAs and 240 unannotated lncRNAs in PTC.
  • Discovered 20 candidate lncRNAs by integrating predicted lncRNA targets with differentially expressed mRNAs.
  • Validated five lncRNAs (CTD-3193O13.11, RP5-1024C24.1, AC007255.8, HOXD-AS1, RP11-402L6.1) with significant differential expression and network characteristics.
  • Found correlations between specific lncRNA expression and clinical parameters like stage, metastasis, tumor size, and patient age.

Conclusions:

  • Provides a genome-wide screening of lncRNA expression in PTC.
  • Highlights the potential involvement of lncRNAs in PTC tumorigenesis and progression.
  • Suggests lncRNAs as potential biomarkers and therapeutic targets for PTC.

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