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Organic Nanoparticle-Based Combinatory Approaches for Gene Therapy

Brahma N Singh1, Prateeksha1, Vijai K Gupta2

  • 1Herbal Nanobiotechnology Lab, Pharmacognosy and Ethnopharmacology Division, CSIR-National Botanical Research Institute, Lucknow-226001, India.

Trends in Biotechnology
|August 19, 2017
PubMed

Insights

Engineered organic nanoparticles (ONPs) offer a novel approach for co-delivering genes and therapies. This technology holds promise for treating genetic and non-genetic disorders by combining gene therapy with other treatments.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Molecular Therapy

Background:

  • Organic nanoparticles (ONPs) are engineered for simultaneous delivery of genetic material and therapeutic agents.
  • This combinatory approach targets both genetic and non-genetic diseases.

Discussion:

  • ONP-mediated co-delivery integrates gene therapy with conventional treatments like chemotherapy, radiotherapy, phototherapy, and immunotherapy.
  • This platform enhances therapeutic efficacy by addressing disease progression through multiple mechanisms.

Key Insights:

  • Engineered ONPs facilitate the co-delivery of genes and diverse therapeutic agents.
  • The ONP platform enables synergistic treatment strategies for various disorders.

Outlook:

  • Further development of ONP-based co-delivery systems is expected to advance precision medicine.
  • This approach has the potential to revolutionize the treatment paradigms for complex diseases.

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