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Related Concept Videos

Gene Therapy00:59

Gene Therapy

27.7K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Combinatorial Gene Control02:33

Combinatorial Gene Control

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Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
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Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Related Experiment Video

Updated: Feb 24, 2026

Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery
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Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery

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Organic Nanoparticle-Based Combinatory Approaches for Gene Therapy.

Brahma N Singh1, Prateeksha1, Vijai K Gupta2

  • 1Herbal Nanobiotechnology Lab, Pharmacognosy and Ethnopharmacology Division, CSIR-National Botanical Research Institute, Lucknow-226001, India.

Trends in Biotechnology
|August 19, 2017
PubMed
Summary

Engineered organic nanoparticles (ONPs) offer a novel approach for co-delivering genes and therapies. This technology holds promise for treating genetic and non-genetic disorders by combining gene therapy with other treatments.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Molecular Therapy

Background:

  • Organic nanoparticles (ONPs) are engineered for simultaneous delivery of genetic material and therapeutic agents.
  • This combinatory approach targets both genetic and non-genetic diseases.

Discussion:

  • ONP-mediated co-delivery integrates gene therapy with conventional treatments like chemotherapy, radiotherapy, phototherapy, and immunotherapy.
  • This platform enhances therapeutic efficacy by addressing disease progression through multiple mechanisms.

Key Insights:

  • Engineered ONPs facilitate the co-delivery of genes and diverse therapeutic agents.
  • The ONP platform enables synergistic treatment strategies for various disorders.

Outlook:

  • Further development of ONP-based co-delivery systems is expected to advance precision medicine.
  • This approach has the potential to revolutionize the treatment paradigms for complex diseases.