Rethinking Schistosomiasis Vaccine Development: Synthetic Vesicles
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Updated: Oct 11, 2026

Expression and Purification of Virus-like Particles for Vaccination
Published on: June 2, 2016
Moses Egesa1, Karl F Hoffmann2, Cornelis H Hokke3
1Department of Medical Microbiology, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala, Uganda; Medical Research Council/Uganda Virus Research Institute Uganda Research Unit on AIDS, Entebbe, Uganda.
Abstract:
There is currently no vaccine against schistosomiasis. With few Schistosoma vaccine candidates in clinical trials, unexplored antigens from the vulnerable schistosomulum should be considered as possible vaccine candidates. In addition, we suggest developing synthetic vesicles as a new delivery vehicle and adjuvant for immunoprophylactic schistosomula vaccine candidates.
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