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Design, synthesis and in vivo study of novel pyrrolidine-based 11β-HSD1 inhibitors for age-related cognitive

Rosana Leiva1, Christian Griñan-Ferré2, Constantí Seira3

  • 1Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia i Cienciès de l'Alimentació, and Institute of Biomedicine (IBUB), Universitat de Barcelona, Av. Joan XXIII 27-31, Barcelona E-08028, Spain.

European Journal of Medicinal Chemistry
|August 19, 2017
PubMed

Keywords:
11β-HSD1 inhibitorsAdamantaneAged-related cognitive dysfunctionAlzheimer's diseaseDrug designGlucocorticoidsPolycyclic substituentsSAMP8 mouse

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