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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

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Lissencephaly in a Pekingese.

Genya Shimbo¹, Michihito Tagawa¹, Eiji Oohashi²

¹Veterinary Medical Center, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido 080-8555, Japan.

The Journal of Veterinary Medical Science

|August 19, 2017

Summary

A Pekingese dog experienced severe seizures due to lissencephaly, a rare brain malformation. This case highlights the challenges in managing neurological disorders in veterinary medicine.

Keywords:

Pekingese lissencephaly magnetic resonance imaging

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Area of Science:

Veterinary Neurology
Comparative Neuroanatomy

Background:

Cluster seizures and behavioral abnormalities in a young dog prompted neurological evaluation.
Prosencephalic lesions were suspected based on clinical presentation.

Observation:

Magnetic resonance imaging revealed a smooth cerebral cortex with reduced gyri (lissencephaly).
A cystic lesion was identified in the quadrigeminal cistern.

Findings:

The dog was diagnosed with lissencephaly and a concurrent quadrigeminal cisternal cyst.
Intractable seizures required high-dose, multi-agent anticonvulsant therapy.

Implications:

This is the first documented case of lissencephaly in the Pekingese breed.
The findings contribute to understanding rare neurological malformations in companion animals.
Effective seizure management in complex neurological cases presents a significant clinical challenge.