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Preparation and Application of Cell Membrane-Camouflaged Nanoparticles for Cancer Therapy
Yihui Zhai1,2, Jinghan Su1,2, Wei Ran1,2
1State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Abstract:
Cancer is one of the leading causes of death worldwide. Many treatments have been developed so far, although effective, suffer from severe side effects due to low selectivity. Nanoparticles can improve the therapeutic index of their delivered drugs by specifically transporting them to tumors. However, their exogenous nature usually leads to fast clearance by mononuclear phagocytic system. Recently, cell membrane-camouflaged nanoparticles have been investigated for cancer therapy, taking advantages of excellent biocompatibility and versatile functionality of cell membranes. In this review, we summarized source materials and procedures that have been used for constructing and characterizing biomimetic nanoparticles with a focus on their application in cancer therapy.
Insights
Cell membrane-camouflaged nanoparticles offer improved cancer therapy by enhancing drug delivery and reducing side effects. This review details their construction and application for targeted cancer treatment.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Cancer remains a leading global cause of death, with current treatments often causing severe side effects due to poor selectivity.
- Nanoparticles show promise for improving cancer therapy by enabling targeted drug delivery to tumors, thus enhancing the therapeutic index.
- The rapid clearance of conventional nanoparticles by the mononuclear phagocytic system limits their clinical efficacy.
Purpose of the Study:
- To review the source materials and construction procedures for cell membrane-camouflaged nanoparticles.
- To summarize characterization techniques for these biomimetic nanoparticles.
- To focus on the application of cell membrane-camouflaged nanoparticles in cancer therapy.
Main Methods:
- Literature review of studies on cell membrane-camouflaged nanoparticles for cancer therapy.
- Analysis of methods for constructing biomimetic nanoparticles using various cell membrane sources.
- Evaluation of characterization techniques for assessing nanoparticle properties and functionality.
Main Results:
- Cell membrane camouflage provides nanoparticles with enhanced biocompatibility and prolonged circulation time.
- These biomimetic nanoparticles demonstrate improved tumor targeting and drug delivery efficiency.
- Various cell membrane sources and fabrication methods can be employed to tailor nanoparticle properties.
Conclusions:
- Cell membrane-camouflaged nanoparticles represent a promising strategy for overcoming the limitations of traditional cancer therapies.
- Their inherent biocompatibility and targeting capabilities offer a versatile platform for advanced cancer treatment.
- Further research into their construction and clinical translation is warranted for effective cancer therapy.
