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Updated: Feb 24, 2026

Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties

Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties

Published on: May 10, 2018

Antimicrobial carbon nanospheres.

Yao-Wen Jiang¹, Ge Gao, Xiaodong Zhang

¹State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, P. R. China. wufg@seu.edu.cn.

|August 19, 2017

Summary

This summary is machine-generated.

Researchers developed novel quaternized carbon nanospheres (QCNSs) using a simple one-pot method. These QCNSs exhibit potent antibacterial activity against Gram-positive bacteria while maintaining excellent biocompatibility.

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Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

Area of Science:

Materials Science
Nanotechnology
Biomedical Engineering

Background:

Carbon nanomaterials offer diverse applications but often require complex synthesis.
Developing efficient and scalable methods for functional carbon nanomaterials is crucial.

Purpose of the Study:

To synthesize novel quaternized carbon nanospheres (QCNSs) via a facile one-pot hydrothermal method.
To evaluate the antibacterial efficacy and biocompatibility of the synthesized QCNSs.

Main Methods:

One-pot hydrothermal treatment of chitosan and hexadecylbetaine (BS-16).
Characterization of the synthesized QCNSs for morphology and size.
Assessment of antibacterial activity using minimum inhibitory concentration (MIC) assays.
Evaluation of cytocompatibility and hemocompatibility.

Main Results:

Successfully synthesized spherical QCNSs with uniform size (∼110 nm).
Achieved significant antibacterial activity against Gram-positive bacteria (MIC: 2.0-5.0 μg mL⁻¹).
Demonstrated excellent cytocompatibility with human liver and lung cells and hemocompatibility with red blood cells.

Conclusions:

The one-pot hydrothermal synthesis offers a novel and efficient route to functional carbon nanomaterials.
QCNSs represent promising metal-free antibacterial agents with potential for biomedical applications.
The antibacterial mechanism involves disruption of bacterial cell walls/membranes by quaternary ammonium groups.