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Updated: Feb 24, 2026
Capture and Release of Viable Circulating Tumor Cells from Blood
Published on: October 28, 2016
Separable Bilayer Microfiltration Device for Label-Free Enrichment of Viable Circulating Tumor Cells
Sijie Hao1,2, Merisa Nisic1,2, Hongzhang He1,2
1Micro & Nano Integrated Biosystem (MINIBio) Laboratory, Department of Biomedical Engineering, Materials Research Institute, and Huck Life Science Institutes, The Pennsylvania State University, N-238 Millennium Science Complex, University Park, PA, 16802, USA.
Abstract:
Analysis of rare circulating tumor cells enriched from metastatic cancer patients yields critical information on disease progression, therapy response, and the mechanism of cancer metastasis. Here we describe in detail a label-free enrichment process of circulating tumor cells based on its unique physical properties (size and deformability). Viable circulating tumor cells can be successfully enriched and analyzed, or easily released for further characterization due to the novel separable two-layer design.
