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Updated: Oct 1, 2026
Biaxial Basal Tone and Passive Testing of the Murine Reproductive System Using a Pressure Myograph
Published on: August 13, 2019
The MMP-9/TIMP-1 imbalance and the reduced level of TGF-β in the cervical area of amniotic membrane is a possible
Małgorzata Litwiniuk1, Małgorzata Radowicka, Alicja Krejner
1Department of Histology and Embryology, Medical University of Warsaw. malgosia.litwiniuk@gmail.com.
Objectives:
To assess the level MMP-9, TIMP-1 and TGF-β in placental and cervical region of amniotic membranes derived from at-term, pre-term and PROM deliveries.
Material And Methods:
14 amniotic membranes have been assessed; the quantitative analysis of MMP-9, TGF-β and TIMP-1 was assayed using respective Quantikine Immunoassay Kit.
Results:
The MMP-9 level in PROM samples was similar to the level of MMP-9 in at-term membranes and comparable between the cervical and placental region of these membranes. The concentration of TGF-β and TIMP-1 was decreased in the cervical area of AM derived from deliveries complicated with PROM.
Conclusion:
The MMP9/TIMP-1 imbalance, as well as the reduced level of TGF-β may be possible risk factors of pre-term labor and PROM.
