Related Experiment Video

Updated: Feb 24, 2026

Continuous IV Infusion is the Choice Treatment Route for Arginine-vasopressin Receptor Blocker Conivaptan in Mice to Study Stroke-evoked Brain Edema
08:44

Continuous IV Infusion is the Choice Treatment Route for Arginine-vasopressin Receptor Blocker Conivaptan in Mice to Study Stroke-evoked Brain Edema

Published on: September 1, 2016

9.3K

Comparison of Clevidipine and Nicardipine for Acute Blood Pressure Reduction in Patients With Stroke

Teresa A Allison1, Stephanie Bowman1, Brian Gulbis1

  • 1Department of Pharmacy, Memorial Hermann-Texas Medical Center, Houston, TX, USA.

Journal of Intensive Care Medicine
|August 19, 2017
PubMed

Insights

Clevidipine and nicardipine showed no significant difference in achieving blood pressure goals for acute stroke patients. Both agents are viable options for managing hypertension in acute ischemic stroke and intracerebral hemorrhage.

Area of Science:

  • Neurology
  • Cardiology
  • Pharmacology

Background:

  • Acute ischemic stroke (AIS) and spontaneous intracerebral hemorrhage (ICH) require prompt blood pressure management.
  • Intravenous antihypertensive agents are crucial for stabilizing patients with acute neurological events.

Purpose of the Study:

  • To compare the efficacy of clevidipine (CLEV) versus nicardipine (NIC) in achieving target systolic blood pressure (SBP) in patients with AIS or ICH.
  • To evaluate secondary outcomes, including hypotension and time to alteplase administration.

Main Methods:

  • Retrospective, observational cohort study of 210 patients with AIS or ICH.
  • Patients received continuous infusion of CLEV or NIC for acute blood pressure management.
  • Data collected on time to goal SBP, hypotension incidence, and time to alteplase.

Main Results:

  • No significant difference in mean time to goal SBP between CLEV (50 min) and NIC (74 min) (P = .101).
  • Hypotension occurred less frequently in the CLEV group (7.1%) compared to the NIC group (10%) (P = .003).
  • No significant differences in percentage change in SBP at 2 hours or time to alteplase administration.

Conclusions:

  • Clevidipine and nicardipine demonstrate comparable effectiveness in achieving blood pressure targets for AIS and ICH patients.
  • Hypotension risk may be lower with clevidipine.
  • Treatment choice between clevidipine and nicardipine should be individualized based on institutional needs and patient factors.
Abstract

Keywords:
acute ischemic strokeantihypertensiveclevidipinehypertensionintracerebral hemorrhagenicardipine

More Related Videos

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

12.7K
Acetylcholine Re-Challenge After Intracoronary Nitroglycerine Administration07:59

Acetylcholine Re-Challenge After Intracoronary Nitroglycerine Administration

Published on: April 4, 2022

1.8K

Related Concept Videos

Antianginal Drugs: Calcium Channel Blockers and Ranolazine01:25

Antianginal Drugs: Calcium Channel Blockers and Ranolazine

Angina pectoris, a primary symptom of ischemic heart disease, requires careful pharmacological interventions. In this context, calcium channel blockers (CCBs) and ranolazine have emerged as crucial pharmacotherapeutic agents, providing deep insights into the complexities of angina management.
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...
1.6K
Antiarrhythmic Drugs: Class IV Agents as Calcium Channel Blockers01:20

Antiarrhythmic Drugs: Class IV Agents as Calcium Channel Blockers

Class IV antiarrhythmic drugs, such as verapamil and diltiazem, block calcium channels. They primarily affect the heart, slowing the conduction in calcium-dependent tissues like the SA and AV nodes. These drugs manage reentrant supraventricular tachycardia (SVT) and reduce ventricular rate in atrial flutter/fibrillation.
Verapamil, a calcium channel blocker, inhibits calcium movement across myocardial cell membranes and vascular smooth muscle. This results in the dilation of coronary and...
2.4K
Antiarrhythmic Drugs: Class I Agents as Sodium Channel Blockers01:22

Antiarrhythmic Drugs: Class I Agents as Sodium Channel Blockers

Class I antiarrhythmic drugs are used to treat various types of arrhythmias or irregular heart rhythms. These drugs block the sodium (Na+) channels in the cardiac cells, thereby affecting the movement of electrical impulses across the heart. Class I antiarrhythmic drugs are divided into three subgroups: Class IA, Class IB, and Class IC, each with distinct mechanisms of action and effects on the heart.
Class 1A Antiarrhythmic Drugs: These drugs work by moderately blocking sodium channels,...
3.8K
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
404
Adrenergic Antagonists: ɑ and β-Receptor Blockers01:31

Adrenergic Antagonists: ɑ and β-Receptor Blockers

Third-generation β-blockers, such as labetalol and carvedilol, represent a significant advancement in managing cardiovascular conditions. Unlike conventional β-blockers, which can induce peripheral vasoconstriction, third-generation drugs block α1 adrenoceptors. This promotes vasodilation through several mechanisms, such as increased nitric oxide production, inhibition of calcium ion entry, opening of potassium ion channels, and antioxidant action. Labetalol, for instance, is...
1.3K
Antihypertensive Drugs: Action of Calcium Channel Blockers01:18

Antihypertensive Drugs: Action of Calcium Channel Blockers

Calcium ions are essential to contract smooth muscle cells in blood vessels. They enter these cells through voltage-dependent calcium channels, specifically L-type calcium channels in the cell membrane. These L-type calcium channels are integral to the excitation-contraction coupling process in smooth muscle. When a stimulus is received by smooth muscle cells, their membrane depolarizes. This alteration in membrane potential instigates the opening of L-type calcium channels. As a result,...
1.9K