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Related Concept Videos

Aging01:26

Aging

894
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

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The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
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Histone Modification02:32

Histone Modification

16.6K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
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Histone Modification02:32

Histone Modification

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Mitochondria01:37

Mitochondria

21.0K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
21.0K

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Related Experiment Video

Updated: Feb 24, 2026

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications
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Histone Modifications in Aging: The Underlying Mechanisms and Implications.

Yuan Wang1, Quan Yuan1, Liang Xie1

  • 1State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Current Stem Cell Research & Therapy
|August 19, 2017
PubMed
Summary

Aging involves functional decline, influenced by epigenetics. This review explores how histone modifications, like methylation and acetylation, are key to aging and potential rejuvenation strategies.

Keywords:
Agingepigeneticshistone acetylationhistone methylationhistone modificationrejuvenation

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Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models
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Area of Science:

  • Gerontology
  • Epigenetics
  • Molecular Biology

Background:

  • Aging is a natural process involving functional decline, influenced by genetics, environment, and epigenetics.
  • Epigenetic alterations, particularly in histone modifications, are increasingly recognized as key drivers of aging.
  • These epigenetic changes are theoretically reversible, offering avenues for intervention.

Purpose of the Study:

  • To review the connection between aging and histone modifications.
  • To focus on major histone modifications involved in aging and their mechanisms.
  • To summarize recent advances in therapeutic strategies targeting histone modifications for aging reversal.

Main Methods:

  • Literature review focusing on histone modifications and aging.
  • Analysis of mechanisms underlying histone methylation and acetylation in aging.
  • Synthesis of current research on interventions targeting histone modifications.

Main Results:

  • Histone post-translational modifications are critical in age-related epigenetic changes.
  • Histone methylation and histone acetylation are prominent modifications linked to aging.
  • These modifications offer potential therapeutic targets for age-related conditions.

Conclusions:

  • Histone modifications are central to epigenetic alterations during aging.
  • Targeting histone methylation and acetylation presents promising strategies for rejuvenation.
  • Intervention in histone modification pathways could reverse aging processes.