Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Flow pattern-dependent endothelial cell responses through transcriptional regulation.

Hiroyuki Nakajima1, Naoki Mochizuki1,2

  • 1a Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute , Suita , Osaka , Japan.

Cell Cycle (Georgetown, Tex.)
|August 19, 2017
PubMed
Summary

Blood flow patterns regulate endothelial cell (EC) functions through distinct gene expression. Key transcription factors like KLF2 and NFκB mediate these responses, influencing vascular health and disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Highly mobile papillary fibroelastoma arising from a left ventricular false tendon.

European heart journal. Case reports·2026
Same author

Artificial Pancreas and Continuous Insulin Infusion for Preventing Cardiac Surgical Site Infections.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026
Same author

[Massive Left Ventricular Thrombus Following Steroid Therapy for Immunoglobulin( Ig) G4-related Ophthalmic Disease:Report of a Case].

Kyobu geka. The Japanese journal of thoracic surgery·2026
Same author

Adverse Hemodynamics in Kommerell's Diverticulum: A Comparative Case Report Linking Oscillatory Shear Index to Aortic Dissection.

Clinical case reports·2026
Same author

Balloon Fracture Fenestration after Frozen Elephant Trunk Deployment to Eliminate Retrograde False-Lumen Perfusion in a Type B Dissection-Complicated Arch Aneurysm.

Surgical case reports·2026
Same author

From Working to Retirement-Age: How Sleep Duration Is Related to Atrial Fibrillation Using 1-Week Holter-Electrocardiogram With Accelerometry.

Circulation reports·2026

Area of Science:

  • Cardiovascular Biology
  • Molecular Biology
  • Mechanobiology

Background:

  • Endothelial cells (ECs) are crucial for vascular homeostasis, responding to mechanical and humoral stimuli from blood flow.
  • Fluid shear stress is a primary mechanical cue influencing ECs, impacting vascular growth, remodeling, and stability.
  • Distinct blood flow patterns elicit differential EC responses, affecting cell turnover and inflammatory states.

Purpose of the Study:

  • To review flow pattern-dependent transcriptional regulation in endothelial cells.
  • To highlight the roles of key transcription factors (KLF2, NFκB, YAP) in mediating EC responses to shear stress.
  • To discuss the spatiotemporal regulation and functional impact of these regulators in vascular health and disease.

Main Methods:

Keywords:
YAPatherosclerosisblood flowshear stresstranscription factor

Related Experiment Videos

  • Review of existing literature on endothelial cell responses to fluid shear stress.
  • Focus on transcriptional regulation mediated by KLF2, NFκB, and YAP.
  • Analysis of how flow patterns influence gene expression and EC function.

    • Main Results:

    • High laminar shear stress promotes EC stability via KLF2, inhibiting cell cycle progression.
    • Low or disturbed shear stress induces EC turnover and inflammation, often mediated by NFκB.
    • YAP emerges as a novel flow-responsive co-regulator involved in blood vessel maintenance.

    Conclusions:

    • Transcriptional regulators like KLF2, NFκB, and YAP are central to endothelial cell adaptation to diverse blood flow patterns.
    • Understanding these flow-dependent regulatory mechanisms is critical for addressing vascular pathologies like atherosclerosis.
    • Targeting these pathways offers potential therapeutic strategies for vascular diseases.