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Related Experiment Videos

Targeting Persistent Human Papillomavirus Infection.

Srinidhi Shanmugasundaram1, Jianxin You2

  • 1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. sshanmu@sas.upenn.edu.

Viruses
|August 19, 2017
PubMed
Summary
This summary is machine-generated.

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Persistent Human papillomavirus (HPV) infections can lead to cancer. This review explores therapeutic vaccines and small-molecule inhibitors to combat existing HPV infections and overcome limitations of prophylactic vaccines.

Area of Science:

  • Virology
  • Immunology
  • Oncology

Background:

  • Human papillomavirus (HPV) infections are common, with most clearing naturally.
  • A significant percentage (10-20%) of HPV infections persist, potentially progressing to invasive cancers.
  • Current prophylactic HPV vaccines are ineffective against pre-existing infections.

Purpose of the Study:

  • To review the mechanisms of persistent HPV infection.
  • To discuss therapeutic strategies for persistent HPV infections.
  • To highlight the potential of immunomodulatory vaccines and small-molecule inhibitors.

Main Methods:

  • Literature review of mechanisms underlying persistent HPV infection.
  • Analysis of therapeutic approaches including immunomodulatory vaccines.
Keywords:
E2 proteinHPVcervical cancerepisome maintenancepersistent infectiontherapeuticsvaccines

Related Experiment Videos

  • Evaluation of small-molecule inhibitors targeting viral-host interactions.

    • Main Results:

    • Persistent HPV infections are a significant cause of cancer.
    • Prophylactic vaccines do not treat established infections.
    • Therapeutic vaccines and small-molecule inhibitors show promise in augmenting host immunity and obstructing viral functions.

    Conclusions:

    • Effective therapies targeting persistent HPV infections are crucial, especially in resource-limited regions.
    • Immunomodulatory vaccines can enhance the host immune response against HPV.
    • Small-molecule inhibitors offer a strategy to disrupt critical viral-host interactions in persistent HPV infections.