Related Experiment Video

Updated: Feb 24, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.3K

The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins

Patrick M Brunner1, Mayte Suárez-Fariñas2,3,4, Helen He2

  • 1The Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY, USA.

Scientific Reports
|August 20, 2017
PubMed

Insights

Atopic dermatitis (AD) is a systemic disease with increased cardiovascular risk. Proteomic analysis revealed distinct inflammatory and cardiovascular markers in AD serum compared to psoriasis, confirming its systemic nature.

Area of Science:

  • Immunology
  • Dermatology
  • Cardiovascular Medicine

Background:

  • Atopic dermatitis (AD) is increasingly recognized as a systemic disease, extending beyond its atopic comorbidities.
  • There is growing evidence linking AD to an increased risk of cardiovascular disease.
  • Understanding the specific protein signatures in AD serum is crucial for defining its systemic nature and associated risks.

Purpose of the Study:

  • To define the serum inflammatory and cardiovascular risk protein profiles in moderate-to-severe atopic dermatitis (AD).
  • To compare the proteomic signature of AD with psoriasis and healthy controls.
  • To investigate the relationship between serum markers, disease severity (SCORAD), and skin inflammation.

Main Methods:

  • Utilized OLINK high-throughput proteomic assay to analyze serum samples from patients with moderate-to-severe AD (n=59), psoriasis (n=22), and healthy controls (n=18).
  • Compared protein expression levels between disease groups and controls.
  • Correlated specific serum protein levels with clinical parameters like SCORAD and BMI, and with skin inflammation markers.

Main Results:

  • 10 proteins, including Th1 and Th17 markers, were elevated in both AD and psoriasis compared to controls.
  • 48 proteins were uniquely upregulated in AD and 48 in psoriasis.
  • AD serum showed distinct upregulation of Th2, Th1, and Th1/Th17/Th22 response markers, alongside novel markers for atherosclerosis, T-cell activation, and angiogenesis.
  • Several atherosclerosis mediators and inflammatory markers in AD serum correlated with SCORAD and/or skin inflammation.

Conclusions:

  • The serum proteomic signature of AD is significantly different from psoriasis, highlighting its distinct systemic inflammatory profile.
  • Elevated levels of cardiovascular risk markers and inflammatory proteins in AD serum support its classification as a systemic disease.
  • These findings underscore the need to consider cardiovascular risk in the management of AD patients.

More Related Videos

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

2.2K
On-Chip Endothelial Inflammatory Phenotyping12:43

On-Chip Endothelial Inflammatory Phenotyping

Published on: July 21, 2012

11.4K

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
633
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
612
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
973
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
605
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.3K
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
760