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Promiscuity, impersonation and accommodation: evolution of plant specialized metabolism
Bryan J Leong1, Robert L Last2
1Department of Plant Biology, Michigan State University, 612 Wilson Road, East Lansing, MI 48824, USA.
Abstract:
Specialized metabolic enzymes and metabolite diversity evolve through a variety of mechanisms including promiscuity, changes in substrate specificity, modifications of gene expression and gene duplication. For example, gene duplication and substrate binding site changes led to the evolution of the glucosinolate biosynthetic enzyme, AtIPMDH1, from a Leu biosynthetic enzyme. BAHD acyltransferases illustrate how enzymatic promiscuity leads to metabolite diversity. The examples 4-coumarate:CoA ligase and aromatic acid methyltransferases illustrate how promiscuity can potentiate the evolution of these specialized metabolic enzymes.
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