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Crossing over is the exchange of genetic information between homologous chromosomes during prophase I of meiosis I. Genetic recombination gives rise to allelic diversity in the newly formed daughter cells. In humans, crossing over produces genetically distinct haploid egg and sperm cells that undergo fertilization to produce unique offspring. Before cell division starts, the germ cell’s chromosome(s) undergo duplication in the S phase of the cell cycle. As the cells enter prophase I,...

Crossing Over

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Updated: Feb 24, 2026

Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR

Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR

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Landscaping Crossover Interference Across a Genome.

Lidan Sun¹, Jing Wang², Mengmeng Sang²

¹Beijing Key Laboratory of Ornamental Plants Germplasm Innovation and Molecular Breeding, National Engineering Research Center for Floriculture, Beijing Forestry University, Beijing 100083, China.

Trends in Plant Science

|August 21, 2017

Summary

This summary is machine-generated.

Crossovers (COs) ensure genetic diversity during meiosis. CO interference, where COs are evenly spaced, is vital for this diversity and occurs across eukaryotic genomes, influencing evolution.

Keywords:

controlled cross crossover interference meiotic crossover multipoint linkage analysis natural population

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Area of Science:

Genetics
Evolutionary Biology
Molecular Biology

Background:

Eukaryotic evolutionary success relies on genetic diversity generated during meiosis via crossovers (COs).
COs are not randomly distributed; they exhibit interference, occurring more evenly across chromosomes.
This crossover interference is a pervasive phenomenon in eukaryotes, potentially conferring a selective advantage.

Purpose of the Study:

To develop and apply a multipoint linkage analysis procedure for quantifying crossover interference strength across the genome.
To illustrate the landscape of crossover interference in natural populations.
To discuss the role of crossover interference in maintaining genetic diversity.

Main Methods:

Multipoint linkage analysis of segregating families.
Genome-wide quantification of crossover interference.
Analysis of crossover interference patterns in natural populations.

Main Results:

A novel procedure for quantifying crossover interference was established.
The genome-wide landscape of crossover interference was mapped.
Patterns of crossover interference in natural populations were elucidated.

Conclusions:

Crossover interference is a significant factor in genome-wide genetic diversity.
Interference patterns vary across natural populations.
Crossover interference plays a crucial role in amplifying and maintaining genetic diversity through various environmental and life-stage factors.