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Updated: Feb 24, 2026

Cell-based Therapy for Heart Failure in Rat: Double Thoracotomy for Myocardial Infarction and Epicardial Implantation of Cells and Biomatrix
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A Complex Heart Team's Approach to a Patient With Giant Cell Myocarditis

Michal Pazdernik1, Ivan Netuka2, Jiri Maly2

  • 1Cardiac Centre, IKEM, Prague, Czech Republic; Department of Cardiology, 2nd Medical School, Charles University Hospital Motol, Prague, Czech Republic.

The Canadian Journal of Cardiology
|August 21, 2017
PubMed

Insights

Giant cell myocarditis is a rare, fatal heart condition. This case study details a patient who successfully underwent heart transplantation after developing acute heart failure.

Area of Science:

  • Cardiology
  • Immunology
  • Transplantation

Background:

  • Giant cell myocarditis (GCM) is a rare and aggressive form of myocarditis.
  • GCM is often associated with a poor prognosis, characterized by rapid heart failure and arrhythmias.

Observation:

  • A previously healthy 64-year-old woman presented with rapid progression of acute heart failure.
  • The patient's condition was diagnosed as giant cell myocarditis.

Findings:

  • Comprehensive heart team care and a wide range of therapeutic interventions were employed.
  • The patient successfully underwent heart transplantation.

Implications:

  • This case highlights the critical role of timely diagnosis and aggressive management in GCM.
  • Successful heart transplantation offers a viable treatment option for select GCM patients.
  • Further research into GCM pathogenesis and treatment strategies is warranted.

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